The GEM report for the region of Querétaro compares the main indicators of GEM Mexico with the local ones, including social values, perceptions, entrepreneurial behavior, and the characteristics of entrepreneurs of new and established business. The report includes the evaluation of the entrepreneurial context made by 38 experts. The region presents very strong values towards entrepreneurship and one of the lowest rates for business discontinuance. Nevertheless, the impact and innovation of new business is an important challenge.